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Cardiometabolic improvements seen from week 0 to week 68 with semaglutide reverted towards baseline at week 120 for most variables

Precautions note that nasal polyps may affect drug absorption and that caution is advised in patients with preexisting cardiovascular disease

The authors would like to thank Megan Khu for critical discussions in written-language

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It addressed accelerated aging in people with HIV (PWH) due to chronic inflammation and metabolic issues, where semaglutide (a GLP-1 agonist) might mitigate these symptoms via weight loss and anti-inflammatory effects