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Because it acts on a different pathway than GLP-1 drugs, the National Institute of Diabetes and Digestive and Kidney Diseases describes how prescription medications treat overweight and obesity by changing appetite signaling rather than relying on willpower

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Outcome measures included changing in the number of positive Tender Points (TPs), the sum of measured pain thresholds (total myalgic score), the SF36, the VAS score for self-perceived stiffness, fatigue, tiredness on awakening, sleep, work status, muscularskeletal pain and the Hamilton depression scale (HADS)

doi:10.1080/13813455.2023.2258559

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