At year 2, the prevalence of prediabetes was reduced with liraglutide 2.4/3.0 mg by over 50%
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(2001) published the foundational preclinical study in Endocrinology demonstrating that the hGH C-terminal fragment inhibits adipogenesis in 3T3-L1 cells, establishing the mechanistic rationale for AOD-9604
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Side effects - primarily gastrointestinal (nausea, vomiting, constipation, and abdominal discomfort) - are well-documented in clinical trial populations and are typically most pronounced during the initial titration phase before the body adapts to rising drug concentrations, which is why the standard-of-care approach involves gradual dose escalation over several weeks or months rather than starting at full therapeutic dose
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