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Along these lines, the SURMOUNT-3 phase III clinical trial revealed that patients with obesity or overweight who achieved 5.0% weight reduction with intensive lifestyle intervention prior to treatment with tirzepatide benefited the most from pharmacotherapy ( 5 Discussion and future directions The prevailing view that IF is cardioprotective largely stems from experimental rodent models and intervention studies ( A major goal for future research will be to identify dietary interventions that both optimally support patients with obesity during pharmacotherapy and maintain the metabolic and cardiovascular benefits achieved during treatment

This unique synergy cannot be achieved with dual agonists

The appropriate response depends on the severity and frequency of symptoms

Large-scale and long-term studies should be conducted to better understand the role of phytochemicals in ASD

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