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Higher Dosages : In some treatment protocols, larger doses of B12 may be required, ranging from 1 ml to 3 ml

Additionally, although the thiolactone form has not been unequivocally identified in vivo , homocysteine could undergo intracellular cyclization into homocysteine thiolactone, which could be a major by-product of impaired homocysteine metabolism (Jakubowski, 1997

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Hippocampus 18 , 435439 (2008)

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The findings closed the loop, linking a metabolite and its transporter to metastasis by demonstrating that mitochondrial glutathione import via the SLC25A39 transporter is essential for cancer spread