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(4) Intracellular TAAR1 activation: Elevated cytoplasmic tyramine activates trace amine-associated receptor 1 (TAAR1), promoting signaling pathways that result in phosphorylation of the NET transporter, modify transporter function to cause it to switch to reverse transport mode (rNET)

After oral administration, its maximum plasma concentration ( C max ) occurs approximately between 1 and 2 h [12]

doi: 10.1016/j.cub.2014.03.034 246 SchmidlinC

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Cell viability assays To evaluate cell viability, 143B and K7M2 cells were seeded in 96-well plates at a density of 5 10 3 cells per well and cultured for 24 h