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TB-500 reconstitution follows a similar protocol: 12 mL of bacteriostatic water per 5 mg vial

Solubility: Highly soluble due to acidic residues

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Other common gastrointestinal effects include: Vomiting (5-24% of patients) Diarrhea (8-30% of patients) Constipation (10-24% of patients) Abdominal pain or discomfort (5-20% of patients) These side effects are typically most pronounced when initiating therapy or increasing doses, and often diminish over time as the body adjusts to the medication

PLoS ONE 7(11)

Mechanistic work suggests that Epithalon may interact with circadian-related genes such as PER1 , a clock gene that can be under-expressed in certain tumor contexts