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Many patients with treatment resistant depression who supplement their SSRIs with methylfolate report improvements in the efficacy of their antidepressants (4)

Natural supplements, however, do not have to undergo these larger studies, and therefore claims from these small initial studies are rarely proven or disproven

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Furthermore, how to combine these different antigens or epitope strings into a single vaccine is not a trivial question

doi: 10.3389/fneur.2022.824926