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The pathophysiology of FM involves central sensitization, low-grade inflammation, and peripheral metabolic disturbances 24
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MHR in the same cells was evaluated by a spectrophotometric assay described by Board and Pidcock (1981), expressed as mol/g Hb/min, and ACP1 activity was measured by the method of Magenis, et al
Previous studies showed that GM could modulate innate immunity and adaptive immunity, involving several immune cells such as T cells, dendritic cells, NK cells and Monocytes/macrophages ( Clostridiales , Ruminococcaceae , and Faecalibacterium spp., exhibit enhanced antigen presentation and improved functionality of effector CD4+ and CD8+ T cells in their peripheral blood (118)
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