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More water makes a less concentrated solution, which can be easier to measure for very small doses

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doi: 10.1002/phar.2017 [PubMed] 29666958 Osman GM, Arajo DF, Maciel CB

When it gets to the end of a strand, its not a perfect fit on the end (the mechanics of this is a little complicated) and needs a bit of scratch DNA at the end of the strand to successfully complete the DNA replication