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To date, clinical trials in humans remain limited, although several are underway or in the planning phase

Smell triggers nausea in many patients

With time, disc bulges or herniations, malalignment of the vertebral segments (spondylolisthesis), osteophyte (bone spur) formation, enlargement (hypertrophy) of facet joints, and ligamentum flavum thickening may all gradually contribute to a narrowing of the spinal canal

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Phase 2 (Jastreboff 2023) cutaneous category 12.9% at 12 mg vs 1.4% placebo

National Healthcare Safety Network hospitalization data are shown only where the reporting fraction was greater than 75%, highlighting the gap in reliable data during this time (May 5, 2024, to November 2, 2024)