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doi:10.1007/s40261-015-0368-5 HerxheimerA, Petrie KJ

Semaglutide showed strong efficacy but with slightly more variability in individual response, suggesting that genetic and biochemical factors influence how effectively each medication works for different people

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Some shared features and mechanisms of action exist, but the active ingredients are different

The between-subject random effect was mouse, and the within-subject repeated measure was preparation condition