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However, large doses of tryptophan (TRP), 5-HTs precursor, failed to sufficiently elevate mood in a double-blind placebo-controlled study with depressed individuals [6]

Yet, a randomized, double-blind, placebo-controlled trial in 215 men (35-55 years old) found that daily supplementation with B vitamins (at 3 to 13 times the current RDA, except for folic acid, which was included at a dose equivalent to the RDA), vitamin C (500 mg/day), zinc (10 mg/day), and magnesium (100 mg/day) for 33 days had no effect on measured performance of executive functions, including the Stroop color-word test, the peg-and-ball task, and the Wisconsin card-sorting task (134)

As the vitamin is difficult to absorb from foods at the levels that raised glutathione in clinical studies, its a common supplement

doi:10.1371/journal.pone.0020456 Berryman et al

Professional guidance is essential for safe and effective supplement use during tirzepatide therapy

Matrixyl, copper peptides, and Argireline all have real, published evidence behind them, and all three show modest, not dramatic, results