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doi: 10.3389/fphar.2026.1768006 Received 15 December 2025 Revised 01 February 2026 Accepted 10 February 2026 Published 25 February 2026 Volume 17 - 2026 Edited by Jianxiang Zhang, Army Medical University, China Reviewed by Fatemeh Saheb Sharif-Askari, University of Sharjah, United Arab Emirates Xiaojing Hou, Nanjing Women and Childrens Healthcare Hospital, China Updates Copyright 2026 Binmahfouz

[146] , but it may also play a role in influencing the progression of thinning

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Although two methoxy residues on the aromatic rings were also required for maximal activity, the addition of further methoxy residues abolished the ability to activate GPR55

There are currently no effective treatments for ALS and therapy is limited to symptomatic and palliative treatment (Bhattacharya et al., 2019)

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