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A pro-oxidative shift caused by GSH depletion triggers glutathionylation of CASP8 at residues Cys360 and Cys409 81

was recorded at 450 nm using a TECAN GENios plate reader

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The potency values, synergy magnitudes, selectivity profiles, and temporal dynamics described here have not been validated in human clinical studies for this specific combination

When there is a suspicion of symptomatic B12 deficiency it is important to measure the B12 serum determination (in addition to excluding other diseases, such as thyroid diseases and Lyme), even if anaemia has not been diagnosed