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Nausea is the most common side effect reported by patients

Weight gain is associated with increased CV risk and a reduction in life expectancy

Based on animal studies, there may be potential risks to an unborn baby from exposure to Compounded GLP-1s during pregnancy

The expression of the target genes in each group were compared using the 2 -CT method and normalized using statistical analysis (the sequence is shown in Supplementary Data 2)

Semaglutide may be unsuitable or require additional caution in patients who: are pregnant, breastfeeding or trying to conceive have a history of pancreatitis have severe gastrointestinal disease have delayed stomach emptying have significant kidney or liver impairment use insulin or medicines that can cause hypoglycaemia have diabetic retinopathy have an active or previous eating disorder have experienced a serious allergic reaction to semaglutide already use another GLP-1 or GIP/GLP-1 medicine are due to undergo surgery, sedation or general anaesthesia These factors are not all automatic exclusions