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Transporters: ABC efflux pumps, especially MRPs, export reduced GSH and GSH conjugates to bile, blood, or luminal spaces, integrating detoxification with redox homeostasis
Phase 3 TRIUMPH-4 (NCT05931367) reported 28.7% body weight loss at 12 mg, 26.4% at 9 mg, vs 2.1% placebo at 68 weeks
The in vivo model utilized 10-week-old male C57BL/6 mice that were housed in environmentally controlled conditions with a 12-hour dark-light cycle, receiving standard laboratory chow and water ad libitum
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It supports: Memory Learning Cognitive function However, excess glutamate can cause neurotoxicity, so balance is crucial