doi: 10.11622/smedj.2018043 133 CohenSJanicki-DevertsDMillerGE
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The hypothesis is that by avoiding -arrestin recruitment, a GLP-1 agonist like CT-996 could lead to less receptor desensitization, decreased internalization, and improved long-term efficacy and tolerability
Leptin deficiency per se dictates body composition and insulin action in ob/ob mice
I'd love to crunch those things
Moreover, the greater stability of the Cagri-induced bypass conformation relative to the rAmy-induced bypass conformation, when engaged with the CTR, is likely a major contributor to the increased conformational stability of the Cagri-AMY 2 R-Gs complex relative to the rAmy-AMY 2 R-Gs complex