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Inter-enzyme substrate diffusion for an enzyme cascade organized on spatially addressable DNA nanostructures

In preclinical safety testing they have a clean record in acute (LD50 testing), repeated study (90 day dosing/histopathologic examination of all tissues at necropsy), and genotoxicity

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Dual synthesis

869 FOXO3 attenuates OA progression by promoting the SLC7A11/GPX4 pathway and inhibiting the NF-B/MAPK pathway, thus inhibiting ferroptosis and extracellular matrix degradation in chondrocytes

[DOI] [PMC free article] [PubMed] [Google Scholar] You J., et al