First identified in the 1990s during research into gastric mucosal protection, BPC-157 has since been studied in numerous animal models for its seemingly broad healing properties
) Method for preparing in vivo formulation: Take L DMSO master liquid, next addL PEG300, mix and clarify, next addL Tween 80, mix and clarify, next add L ddH 2 O, mix and clarify
10 In this study, BPC-157 showed a dose-dependent effect compared to the control during phase 1, but it showed little effect during phase 2
What they found: Preventive administration: 70 to 85 % reduction in ulcer area Therapeutic administration: 60 to 75 % reduction And now the most interesting part: 10 ng/kg worked just as well as 10 g/kg Why it matters: If the molecule worked in a stoichiometric way (= simply blocking something piece by piece), a higher dose would necessarily produce a larger effect
For example, a 10 mg vial with 1 mL of water gives 10 mg/mL
[DOI] [PubMed] [Google Scholar] [185].Kim LM, Morley PS, Traub-Dargatz JL, Salman MD, Gentry-Weeks C