The 20 bp genomic sgRNA target sequence with a 3 bp PAM (underlined) used in this study is shown as follows: sgAlb-E14 (GTTGTGATGTGTTTAGGCTA AGG ), targeting exon 14 of the mouse Albumin ( Alb ) locus
Furthermore, the cost of IVNT and lack of insurance coverage make it less accessible than oral supplementation for many patients
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Instead, the body simply returns to regulating growth hormone production without the additional stimulation provided by the peptide