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Notably, this polymorphism reduces deiodinase type 2 enzymatic velocity by about 20% and might explain the lower serum T3 in LT4-treated hypothyroid carriers (14, 29)
Moreover, some combinations may help mitigate the side effects associated with individual drugs or even provide supplementary health benefits, such as weight loss or reduced blood pressure, which are particularly beneficial in the diabetic population
doi:10.3238/arztebl.2017.0653 [22] Peckham S, Lowery D, Spencer S
