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56 Many drugs are substrates for Pgp, which limits their accumulation in the brain

Arendt et al., 2013)

- Lithium: because it reduces the renal clearance and increases lithium levels in plasma which increases the risk of lithium toxicity

Globally, many in vitro and animal-based studies have demonstrated such preventive anticancer activity in colon, cervical, prostate, breast and lungs [50,64,65,66,67,68,69]

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