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Amino acid metabolism disorders have been linked with a number of pathological conditions, including metabolic diseases, cardiovascular diseases, immune diseases, and cancer

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Other health conditions: The presence of cardiovascular disease, kidney problems, or other conditions may influence the choice of GLP-1

Circulation 1992

The deficiency of free CoA limits the efficiency of the Krebs cycle in activating anaerobic glucose metabolism (which inhibits pyruvate dehydrogenase activity, which is responsible for the conversion of pyruvate to acetyl-CoA in aerobic glucose metabolism in cells of the human organism), causing an increase in the concentration of toxic lactate in tissues [58,78,79]