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Readers are encouraged to consult the primary publication (Rosenstock et al., The Lancet, 2023) and the ClinicalTrials.gov record for full participant numbers, confidence intervals, and protocol details

In practice, the patients most likely to see meaningful improvement are those with clear signs of metabolic dysfunction

Nyborg, N

Experiencing these symptoms can be alarming, especially when they happen suddenly or persist over time

The answer to the question, Do we need drugs to preserve muscle mass during weight loss? is a resounding Yes, especially for an aging population!

Both doses are increased gradually over several weeks to improve tolerability