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When alkaline phosphatase was engineered to remain in the cytoplasm of live cells, unnaturally high concentrations of hydrogen peroxide were required to oxidize it to its active, disulfide-dependent form, and toxic levels of superoxide had no effect

mTORmembrane and RAPTORmembrane interactions The cryo-EM reconstruction showed that mTOR and RAPTOR subunits directly interact with the membrane, in addition to the expected membrane attachment by lipidated LAMTOR1 and RHEB (Fig

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Pharmacol Res 158:104844 Kamarajan P, Rajendiran TM, Kinchen J, Bermdez M, Danciu T, Kapila YL (2017) Head and neck squamous cell carcinoma metabolism draws on glutaminolysis, and stemness is specifically regulated by glutaminolysis via aldehyde dehydrogenase