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Jorsal A, Wiggers H, Holmager P, Nilsson B, Nielsen R, Boesgaard TW, Kumme A, Mller JE, Videbk L, Kistorp C

Neurobiol Dis 2015

The oral route proved as effective as parenteral injection in these gut models, underscoring the point about the peptide's unusual stability

It is also not recommended for patients with severe gastrointestinal disease, such as severe gastroparesis

Along these lines, the SURMOUNT-3 phase III clinical trial revealed that patients with obesity or overweight who achieved 5.0% weight reduction with intensive lifestyle intervention prior to treatment with tirzepatide benefited the most from pharmacotherapy (70)

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