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Large-scale clinical trials have demonstrated that GLP-1RAs predominantly exhibit neutral or suppressive effects on overall cancer risk, with semaglutide showing no elevated cancer incidence [14], while significant reductions have been observed in specific malignancies, particularly liver cancers and prostate cancers [13, 15]

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Also, there is growing concern regarding concussion-induced cortical damage seen in children and young adults who participate in American football (chronic traumatic encephalopathy), boxing, martial arts, and soccer (due to headers) [35,36]

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According to Mercks financial report, Keytrudas Q1 2025 sales reached $7.21 billion, up 4% year-over-year, but with a quarter-over-quarter decline for the first time

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