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This is due, in part, to high rates of aerobic metabolism, particularly in the proximal tubules

CagA modulates host cell iron homeostasis and fundamental metabolic functions of the bacterial cell, promoting the synthesis of polyunsaturated ether phospholipids (PUFA-ePLs) through increased expression of alkylglycerone phosphate synthase and 1-acylglycerol-3-phosphate O-acyltransferase 3, resulting in susceptibility to ferroptosis in GC cells [49]

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Notably, semaglutide and exenatide showed higher NAE proportions (16.97% and 14.44%, respectively) compared to tirzepatide (6.06%)

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