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Based on the NOS criteria, four studies were classified as high-quality [27, 28, 32, 33], and one study was rated as medium-quality [40]

Severe cases of cleft lip appear as a gap or opening in the lip that extends up into the nose

Core histones are key targets, with H2A monoubiquitination essential for neurodevelopment and linked to related disorders (Srivastava et al., 2017

The endothelial layer, composed of tightly packed cells connected by tight junctions, forms a highly selective physical and biochemical barrier known as the BBB [3]

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