So statements that topical AHK-Cu is "well tolerated" rest on the copper-peptide class generally much of it built on GHK-Cu (Pickart & Margolina 2018, PMID 29986520) and on community use, rather than on dedicated AHK-Cu safety study
Legitimate supplements use structure/function claims ("supports healthy metabolism"), not drug claims ("treats obesity")
Additionally, some people report that evening injection reduces next-day fatigue
Lyophilized: Hold the dry vial at 28 C for short-term use or 20 C (4 F) for longer storage, in dry, dark conditions [6]
Furthermore, in liver, Chac1 protein is moderately expressed, whereas Chac2 protein is undetectable (21)
This high energy demand makes the kidneys vulnerable to stress, and accumulating data suggests that changes in NAD + metabolism are linked to CKD progression 292,295,296