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While glucose and oxygen concentrations did not vary between groups, IGF-1 LR3 treatment significantly reduced circulating amino acids, notably branched-chain amino acids, known to promote GSIS and protein accumulation to support fetal growth

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These insights open new avenues for research into pathogenesis and the investigation of targeted approaches based on the modulation of proteasomal function

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New England Journal of Medicine, 384(11):9891002