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Glucoregulatory effects and prolonged duration of action of davalintide: a novel amylinomimetic peptide

The existing evidence base consists primarily of: Small observational studies in patients with diabetes who also have inflammatory conditions Mechanistic studies exploring theoretical anti-inflammatory pathways Indirect evidence from cardiovascular outcome trials showing reduced inflammatory markers in people with type 2 diabetes (which cannot be extrapolated to rheumatoid arthritis or to microdosing) NICE guidance for rheumatoid arthritis management (NG100) does not include GLP-1 receptor agonists among recommended treatment options

GLP-1-directed NMDA receptor antagonism for obesity treatment

Peptide therapies should always be used under medical supervision

Both methods can improve B12 levels, but professional injections may suit those with specific health concerns

[PMC free article: PMC185999] [PubMed: 8675659] 265