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Standard research protocols often run for 4 to 8 weeks, followed by an off-period of at least the same length

Buschmann, I

Consistent with our findings, a recent study on the dihydroorotate dehydrogenase (DHODH)-mediated mitochondria ferroptosis defense system also points to the role of mitochondrial iron in ferroptosis 57

Mitochondrial 1C metabolism converts serine into glycine, NADPH, and a serine-derived carbon unit (red ball), which is shuttled into the cytosol for use in purine and thymidylate biosynthesis

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