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63, 64 Interestingly, the presence of proinflammatory cytokines and activated neuroglia have been reported in the autism cerebellum among other regions, 9 suggesting that activated neuroglia produce excess NO and may contribute to the peroxynitrite formation and increased 3-NT protein damage observed in the present study

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The most-developed and most-distinctive research application for 5-Amino-1MQ is in adipose tissue biology , anchored on a landmark 2014 Nature paper by Kraus and colleagues that established NNMT as a central regulator of adipose energy metabolism

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5-Amino-1MQ is a small molecule that selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme involved in NAD+ metabolism

doi: 10.3389/fmicb.2025.1580171 166 WangT.PanD.ZhouZ.YouY.JiangC.ZhaoX.et al