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Moreover, the rate of sinusoidal GSH efflux in both fed and starved rats is near saturation at about 80% of Vmax, about 10001200 M/h [34]

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Human Trx and GSH systems have compensatory activities so that inhibition of one arm can be supplemented by the other 60 , suggesting that the inhibition of hTrxR by some of the compounds presented here will not be detrimental for humans as it is for schistosomes

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