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Lau W, Kato H, Nosaka K

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To further compare GSH synthetic capacities of different pathways, GSH1 gene of engineered strain W303-1b/F was deleted to eliminate synthesis of GSH by endogenous enzymes

Notably, bi-allelic MC4R mutation carriers had long-term outcomes as poor as those with bi-allelic LEPR or POMC mutations, suggesting that biallelic mutations in LMP genes generally lead to more severe impairment of surgical efficacy compared to heterozygous mutations

Diabetologia 58 , 221232 (2015)