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"These drugs are thought to work by engaging part of the brain called the hypothalamus, which helps regulate a wide variety of hormones," says Jena Shaw Tronieri, Senior Research Investigator at Penn's Center for Weight and Eating Disorders and a co-author of the study

In the same population, 24-h spontaneous GH levels also predominantly correlated inversely with intra-abdominal fat mass (29)

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Regarding GLP-1RAs and diabetic kidney disease, beneficial effects on composite renal outcomes have been reported, mainly the prevention of new-onset macro-albuminuria, albeit more evidence is needed to establish therapeutic benefits in clinical settings [2,264]