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Participants were excluded from the trial if any of the following criteria applied: Glycemia-related HbA 1c 48 mmol mol 1 (6.5%) as measured by the central laboratory at screening

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By helping to increase the production of red blood cells, vitamin B12 may improve oxygen delivery to the muscles during exercise

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The hypertension-related variant rs1275988, located in a cell-type-specific enhancer, aggravates hypertension by regulating local DNA methylation, Kcnk3 expression, and subsequent vascular remodeling