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It includes 1-5 intramuscular or subcutaneous injections of 1000 mcg crystalline cyanocobalamin daily, followed by oral doses of 1000-2000 mcg/day Parenteral administration should be reserved for those with significant neurological symptoms NICE guideline: Vitamin B 12 deficiency in over 16s: diagnosis and management: Malabsorption as the confirmed or suspected cause of vitamin B 12 deficiency: Offer replacement to people if: lifelong intramuscular vitamin B12 Autoimmune gastritis is the cause They have had a total gastrectomy They have had a complete terminal ileal resection If the person has a vitamin B 12 deficiency because of malabsorption that is not caused by autoimmune gastritis, or a total gastrectomy or complete terminal ileal resection (for example, malabsorption caused by coeliac disease, partial gastrectomy or some forms of bariatric surgery): Offer vitamin B 12 replacement and Consider intramuscular instead of

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Research Context Synthetic peptide fragment derived from a gastric protein sequence Investigated in tissue signalling and regenerative response models Studied in vascular activity and cellular communication pathways Explored in controlled preclinical laboratory environments Mechanism Exploration Areas Cellular signalling pathway investigation Angiogenic and vascular response research models Protein interaction and receptor pathway studies Tissue repair and regenerative signalling exploration BPC-157 UK Research Context BPC-157 peptide research continues to attract interest in experimental settings where investigators are exploring tissue-related signalling pathways, vascular responses and cellular recovery mechanisms

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