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In those cases, semaglutide may help regulate appetite and support more lasting results

This contrasts with the compensatory increase in appetite typically observed with other dietary approaches [134]

Clinical trials show that meaningful weight losstypically 510 poundsbecomes noticeable between weeks 2 and 4 for many patients

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Large observational studies have found that people with Type 2 diabetes who take semaglutide and other GLP-1 medications appear to have lower rates of Alzheimers dementia, vascular dementia, and stroke compared to those using other diabetes treatments

It is not yet FDA approved, but Phase 3 data from the TRIUMPH-4 trial (December 2025) showed an average of 28.7% body weight loss at 68 weeks at the 12 mg dose the highest ever recorded in a pharmacological weight loss trial