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In the hippocampus, Doxorubicin and Cyclophosphamide treatment significantly reduced CAT levels compared to the control group by 2.58 folds

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A proof of the dynamic balancing of carnitine homeostasis derives from the observation that, under regular diet, patients carrying defects of the carnitine biosynthesis enzymes, do not apparently display carnitine deficiency, because the reduced synthesis is compensated by carnitine dietary intake and increased renal reabsorption (Stanley et al., 1992

This remains preliminary, but it aligns with broader evidence linking GH-IGF-1 signalling to neurological health in ageing populations

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