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Model Mech

The two primary endpoints were the Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS, which ranges from 0 to 100) and the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS)

While traditionally described as being absorbed directly through the mucous membranes in the mouth, research suggests that much of the dose is actually swallowed and absorbed through the digestive system via passive diffusion, similar to standard oral tablets

218 , e20201993 (2021)

This approach isolates any adverse effects to the new agent rather than conflating them with tirzepatide's known tolerability profile

doi: 10.1111/mpp.12661 12 DeanJ