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There was no correlation between the basal levels of GPX4 and SLC7A11 proteins and the sensitivity to APR-246 ( Online Supplementary Figure S6A and B )

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Metabolite analysis by LCMS/MS and NMR All NMR experiments were performed on a Bruker AVANCE III 500 NMR spectrometer equipped with a room temperature z -gradient TXI probe and operating at 1 H and 13 C frequencies of 500.13 MHz and 125.76 MHz, respectively

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Following administration of 0.25 mg digoxin concomitantly with 100 mg of Januvia daily for 10 days, the plasma AUC of digoxin was increased by 11%, and the plasma Cmax by 18%