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HIV protease inhibitors elicit volume-sensitive Cl- current in cardiac myocytes via mitochondrial ROS

Lean mass loss is an important clinical concern during GLP-1 weight loss therapy, with studies suggesting that 25-40% of total weight lost may be lean tissue

The Double Mechanism of Risk Increased Ketogenesis from Lower Insulin When insulin levels drop: Fat breakdown increases Free fatty acids are converted to ketones in the liver Blood ketone levels rise Even if glucose levels are normal or mildly elevated, ketone accumulation can lead to metabolic acidosis

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This article unpacks the mixed evidence and offers practical guidance for clinicians