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When we mutated the cleavage site from UUGCAA to UUCCAA, fragment #4 as well as the full-length fragment was no longer cleaved by IRE1 (Fig

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Keywords: hyperthyroidism, thyroid disease, blood sugar control, glucose stability, carbimazole, methimazole, propylthiouracil, antithyroid drugs, type 2 diabetes mellitus, graves' disease Introduction and background In clinical practice, patients with multiple endocrine diseases who take multiple medications commonly experience many side effects