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Self-sourcing and self-dosing without medical supervision is strongly discouraged, particularly for autoimmune patients who are often on complex medication regimens

The FDA advises health care providers to monitor patients carefully for kidney disease, eye disease, depression or suicidal behaviors or thoughts

On the other hand, metformin is a generic drug that is known by the brand names Glucophage, Fortamet, and Riomet

Therefore, leucine represents the BCAA with the most compelling mechanistic and clinical evidence relevant to musclevascular interactions and healthy aging, justifying its emphasis in the present review