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It is still of note that with the excessive number of articles that were produced from the initial search, only 32 articles truly discussed the perioperative risks and management of patients taking GLP-1 RAs and undergoing anesthesia/sedation

11 Elevated cortisol can negatively impact metabolism, promote fat storage (especially abdominal fat), disrupt other hormones involved in appetite regulation, increase cravings (particularly for high-sugar, high-fat foods), and contribute to insulin resistance, potentially hindering weight loss efforts despite medication and diet changes

10.1016/j.ccm.2024.08.007 14 ChenL.ZhangF.KongD.ZhuX.ChenW.WangA.et al (2013)

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The results from these recently completed trials support the findings of the HIV study, said Sekhar, who is currently the Principal Investigator of two NIH-funded randomized clinical trials studying the effect of GlyNAC in older humans with mild cognitive impairment, and with Alzheimers disease