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Some patients achieve their goals on lower doses like 5 milligrams and can remain stable there long-term without further increases

Achievement of T2DM remission following BS is multi-factorial but largely driven by weight loss-related improvements in insulin sensitivity and -cell function, and there are also documented changes in gut physiology, bile acid metabolism, and gut microbiota that appear to have benefits on glycemia [218]

Clinics should have sedation-trained staff on-site during non-anesthetic infusions, as required by Utah law

Sometimes patients assume these symptoms are caused entirely by the medication itself, when nutrition may actually be playing a major role

Escalating before day 14 stacks new nausea on top of resolving nausea, which is the primary driver of discontinuation

Long-term unsupervised use is discouraged