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Brain struct Funct 226(1):225245 Xie Z, Enkhjargal B, Wu L, Zhou K, Sun C, Hu X, Gospodarev V, Tang J, You C, Zhang JH (2018) Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats

Key findings: Used daily Used continuously Used for months , not weeks Demonstrated safety without tolerance development No cycling protocols were included

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The initial level upon admission can be normal , with delayed emergence of toxicity

Risk Factors include age (it usually affects people over 50), diabetes, hypertension, high cholesterol, sleep apnea, and anatomical predispositions such as a small cup-to-disc ratio